顾建兰

姓名：顾建兰

职称：教授

个人简介：江苏南通人，医学博士。

专业研究领域：神经退行性疾病的病理机制及防治。

专著与论集：

1.Yang M, Qi R, Liu Y, Shen X, Zhao Y, Jin N, Wu R, Liu F*, Gu J*. Casein Kinase 1δ Phosphorylates TDP-43 and Suppresses Its Function in Tau mRNA Processing. J Alzheimers Dis. 2023;91(4):1527-1539.

2.Wu R, Zhou D, Shen X, Chen F, Liu F*, Gu J*. Phosphorylation of Trans-active response DNA binding protein of 43 kDa promotes its cytoplasmic aggregation and modulates its function in tau mRNA stability and exon 10 alternative splicing. J Neurochem. 2021 Aug; 158(3):766-778.

3.Gu J*, Liu F. Tau in Alzheimer’s disease: pathological alterations and an attractive therapeutic target. CURR MED SCI. 2020 Dec;40(6):1009-1021.

4.Gu J^#, Xu W^#, Jin N, Li L, Zhou Y, Chu D, Gong CX, Iqbal K, Liu F*. Truncation of tau selectively facilitates its pathological activities. J Biol Chem. 2020 Oct 2;295(40):13812 -13828.

5.Gu J, Hu W, Tan X, Qu S, Chu D, Gong CX, Iqbal K, Liu F*. Elevation of Casein kinase 1ε is associated with TDP-43 and tau pathologies in Alzheimer's disease. Brain Pathol. 2020 Mar; 30(2): 283-297.

6.Gu J*, Chu D, Jin N, Chen F, Liu F*. Cyclic AMP-Dependent Protein Kinase Phosphorylates TDP-43 and Modulates Its Function in Tau mRNA Processing. J Alzheimers Dis. 2019;70(4): 1093-1102.

主要科研项目

主持多项省部级以上科研项目，其中包括国家自然科学基金项目2项，江苏省自然科学基金项目1项。

讲授课程

生物化学与分子生物学

指导研究生情况

已毕业硕士生1名；在读硕士生2名。