姓名：钱慰
职称：教授，博士生导师
个人简介：1987年至1991就读于南京大学生物系，获学士学位。2004年至2009年就读于中科院上海生物化学与细胞生物学研究所，生物化学与分子生物学专业，获博士学位。2002年，2010年两次作为访问学者在美国纽约州立发展障碍基础研究所著名早老性痴呆研究专家Dr. Kalid Iqbal教授的实验室进行Tau蛋白相关AD病理机制的研究。1997年至今任教于南通大学医学院生物化学与分子生物学系，教授，博士生导师，生物化学与分子生物学系主任。
专业研究领域：研究方向为神经退行性疾病的病理机制及其防治。主要围绕Tau相关阿尔茨海默（AD）病理机制展开研究，涉及Tau蛋白的表达，可变剪接异构体，翻译后修饰等多个不同层面。特别关注SIRT1对Tau的调节在早期AD相关突触功能障碍中的作用，为AD早期防治的药物开发提供基础研究依据。
专著与论集：
1. SIRT1 deficiency increases O-GlcNAcylation of tau, mediating synaptic tauopathy, Xiaomin Yin, Yuanyuan Li, Xing Fan, Fang Huang, Yanyan Qiu, Chenhao Zhao, Zheng Zhou, Qun Gu, Liye Xia, Junze Bao, Xiaochuan Wang, Fei Liu, and Wei Qian, Mol Psychiatry, 2022 Jul 25. doi: 10.1038/s41380-022-01689-2.
2. Tau Acts in Concert With Kinase/Phosphatase Underlying Synaptic Dysfunction, Xing Fan, Liye Xia, Zheng Zhou, Yanyan Qiu, Chenhao Zhao, Xiaomin Yin and Wei Qian, Front Aging Neurosci, 2022 May 27;14:908881. doi: 0.3389/fnagi.2022.908881. eCollection 2022
3. Dendritic/Post-synaptic Tau and Early Pathology of Alzheimer’s Disease, Xiaomin Yin, Chenhao Zhao, Yanyan Qiu, Zheng Zhou, Junze Bao and Wei Qian, Front Mol Neurosci, 2021 Jun 25;14:671779. doi: 10.3389/fnmol.2021.671779. eCollection 2021
4. SIRT1 Regulates Tau Expression and Tau Synaptic Pathology, Xiaomin Yin, Zheng Zhou, Yanyan Qiu, Xing Fan, Chenhao Zhao, Junze Bao, Chenxu Liu, Fei Liu and Wei Qian, J Alzheimers Dis, 2021;84(2):895-904
5.The Role of Amyloid-Beta and Tau in the Early Pathogenesis of Alzheimer’s Disease, Xiaomin Yin, Yanyan Qiu, Chenhao Zhao, Zheng Zhou, Junze Bao, Wei Qian, Med Sci Monit, 2021; 27: e933084 DOI: 10.12659/MSM.933084
6. SIRT1 regulates O-GlcNAcylation of tau through OGT, Shu Lu, Xiaomin Yin, Jia Wang , Qun Gu , Qin Huang, Nana Jin, Dandan Chu, Ziqi Xu, Fei Liu, Wei Qian, Aging (Albany NY), ,2020 Apr 20;12(8):7042-7055.
7. Sirt1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice, Shuo Qian, Jianlan Gu, Wufei Dai, Nana Jin, Dandan Chu, Qin Huang, Fei Liu, Wei Qian, Aging. 2018;10(9):2498-2510.
8. SIRT1 Deacetylates SC35 and Suppresses Its Function in Tau Exon 10 Inclusion, Xiaomin Yin, Xiaosu Jiang, Jia Wang, Shuo Qian, Fei Liu, Wei Qian, J Alzheimers Dis., 2018;61(2):561-70.
9. PKA-CREB Signaling Suppresses Tau Transcription, Huanliang Liu, Xiaoxia Jin, Xiaomin Yin, Nana Jin, Fei Liu, Wei Qian, J Alzheimers Dis., 2015, 46(1):239-48.
10. Regulation of alternative splicing of tau exon 10, Wei Qian, Fei Liu, Neurosci Bull., 2014;30(2):367-77.
11. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) enhances tau expression, Wei Qian, Nana Jin, Jianhua Shi, Xiaomin Yin, Xiaoxia Jin, Shibao Wang, Maohong Cao, Khalid Iqbal, Cheng-Xin Gong, Fei Liu, J Alzheimers Dis., 2013.;37(3):529-38.
12. Regulation of the alte Regulation of alternative splicing of tau exon 10rnative splicing of tau exon 10 by SC35 and Dyrk1A, Wei Qian, Hongwei Liang, Jianhua Shi, Nana Jin, Inge Grundke-Iqbal, Khalid Iqbal, Cheng-Xin Gong, Fei Liu Nucleic Acids Res. 2011, 39(14):6161-71.
13. Splicing factor SC35 promotes tau expression through stabilization of its mRNA, Wei Qian, Khalid Iqbal, Inge Grundke-Iqbal, Cheng-Xin Gong, Fei Liu, FEBS Lett. 2011, 585(6):875-80
14. Activation of Protein Phosphatase 2B and Hyperphosphorylation of Tau in Alzheimer's Disease, Wei Qian , Xiaomin Yin, Wen Hu , Jianhua Shi, Jianlan Gu , Inge Grundke-Iqbal, Khalid Iqbal, Cheng-Xin Gong, Fei Liu, J Alzheimers Dis. 2011; 23(4):617-27.
15. PP2A Regulates Tau Phosphorylation Directly and also Indirectly via Activating GSK-3beta, Wei Qian, Jianhua Shi, Xiaomin Yin, Khalid Iqbal, Inge Grundke-Iqbal, Cheng-Xin Gong, Fei Liu, J Alzheimers Dis. 2010; 19(4):1221-9.
16. Purification and characterization of Stn1p, a single-stranded telomeric DNA binding protein, Wei Qian,Xiao-Hong Fu,Jin-Qiu Zhou, Protein Expr Purif. 2010 ;73(2):107-12.
17. Ten1p promotes the telomeric DNA-binding activity of Cdc13p: implication for its function in telomere length regulation, Wei Qian, Jianyong Wang, Na-Na Jin, Xiao-Hong Fu, Yi-Chien Lin, Jing-Jer Lin, Jin-Qiu Zhou, Cell Res. 2009; 19(7):849-63.
主要科研项目
主持国家自然科学基金项目3项，江苏省自然科学基金面上项目1项。
讲授课程
生物化学与分子生物学，高级生物化学，医学生物化学进展
指导研究生情况
硕士研究生导师，博士研究生导师
