刘晓娟

发布时间:2023-07-21录入员:


                                                    

姓 名

刘晓娟

性别

专业技术职称

教授

学科专业

病原生物学

 

南通大学

电子邮箱

lxj@ntu.edu.cn

联系电话(办公)

0513-850519999

个人简历

刘晓娟,女,19751020日出生,江苏如皋人,复旦大学基础医学院生物化学与分子生物学专业博士毕业,现为南通大学医学院病原生物学系教授。本人一直致力于疾病的炎症机制研究,迄今为止以第一作者或者通讯作者发表SCI论文40篇,以第一发明人获得国家发明专利3项,并转让专利权2项。

教育经历(按时间倒序排序)

2011/09-2014/07 复旦大学,基础医学院,生物化学与分子生物学,博士,导师:顾建新教授

2001/09-2004/07 南通大学,医学院,免疫学,硕士,导师:钱虎教授

1994/09-1999/06 南通医学院,临床医学,学士

工作经历(科研与学术工作经历,按时间倒序排序)

2020/07-至今南通大学,医学院,病原生物学系,教授

2014/07-2020/08 南通大学,医学院,病原生物学系,副教授

2011/01-2014/06 南通大学,医学院,病原生物学系,讲师

2005/01-2010/12 南通大学,医学院,微生物学与免疫学教研室,讲师

1999/08-2004/12 南通大学,医学院,微生物学与免疫学教研室,助教

研究领域

疾病的炎症机制

代表性成果(论文、专著、专利等)

论文(按时间倒序排序)

[1] Zeng J, Wu M, Zhou Y, Zhu M, Liu X#. Neutrophil Extracellular   Traps (NETs) in Ocular Diseases: Biomolecules. 2022 Oct   8;12(10):1440.

[2] Wang   Y, Xie L, Zhu M, Guo Y, Tu Y, Zhou Y, Zeng J, Zhu L, Du S, Wang Z, Zhang Y, Liu X#,   Song E. Shikonin alleviates choroidal neovascularization by inhibiting   proangiogenic factor production from infiltrating macrophages. Exp Eye Res.   2021 Dec;213:108823.

[3] Zhou Y,Zeng J, Tu Y, Li L, Du S, Zhu L,   Cang X, Lu J, Zhu M, Liu X#. CSF1/CSF1R-mediated   Crosstalk Between Choroidal Vascular Endothelial Cells and Macrophages   Promotes Choroidal Neovascularization. Invest Ophthalmol Vis Sci. 2021 Mar   1;62(3):37.

[4] Tu Y, Song E, Wang   Z, Ji N, Zhu L, Wang K, Sun H, Zhang Y, Zhu Q, Liu X#, Zhu M. Melatonin attenuates oxidative stress and   inflammation of Müller cells in diabetic retinopathy via activating the Sirt1   pathway. Biomed Pharmacother. 2021 May;137:111274.

[5] Liu X*, Guo A, Tu Y, Li W, Li L, Liu W, Ju Y, Zhou Y, Sang   A, Zhu M. Fruquintinib inhibits   VEGF/VEGFR2 axis of choroidal endothelial cells and M1-type macrophages to   protect against mouse laser-induced choroidal neovascularization.Cell Death Dis. 2020 Nov 27;11(11):1016.

[6] Liu W, Xu W, Chen Y, Gu L, Sun X, Qu Y, Zhang H, Liu   X#, Huang H.Elevated   double-strand break repair protein RAD50 predicts poor prognosis in hepatitis   B virus-related hepatocellular carcinoma: A study based on Chinese high-risk   cohorts. J Cancer.   2020 Aug 14;11(20):5941-5952.

[7] Wang Y, Liu X*, Zhu L, Li W, Li Z, Lu X, Liu J, Hua W, Zhou Y, Gu Y, Zhu M. PG545   alleviates diabetic retinopathy by promoting retinal Müller cell autophagy to   inhibit the inflammatory response. Biochem Biophys Res Commun. 2020 Oct   22;531(4):452-458.

[8] Li W, Liu X*, Tu Y, Ding   D, Yi Q, Sun X, Wang Y, Wang K, Zhu M, Mao J. Dysfunctional Nurr1 promotes high glucose-induced   Müller cell activation by up-regulating the NF-κB/NLRP3 inflammasome axis. Neuropeptides. 2020 Aug;82:102057.

[9] Tonello   R, Xie W, Lee SH, Wang M, Liu X, Strong JA, Zhang JM, Berta T.   Local Sympathectomy Promotes Anti-inflammatory Responses and Relief of   Paclitaxel-induced Mechanical and Cold Allodynia in Mice. Anesthesiology.   2020 Jun;132(6):1540-1553.

[10] Tu   Y, Zhu M, Wang Z, Wang K, Chen L, Liu W, Shi Q, Zhao Q, Sun Y, Wang X, Song   E, Liu X#. Melatonin inhibits Müller cell activation   and pro-inflammatory cytokine production via upregulating the   MEG3/miR-204/Sirt1 axis in experimental diabetic retinopathy. J Cell Physiol.   2020 Nov;235(11):8724-8735.

[11] Liu X*, Tonello R, Ling Y, Gao YJ, Berta T. Paclitaxel-activated   astrocytes produce mechanical allodynia in mice by releasing tumor necrosis   factor-α and stromal-derived cell factor 1. J Neuroinflammation. 2019 Nov   10;16(1):209.

[12] Liu X*, Zhu M, Ju Y, Li A, Sun X. Autophagy dysfunction in neuropathic   pain. Neuropeptides. 2019 Jun;75:41-48.

[13] Shen   Y, Liu X*, Shi J, Wu X. Involvement of Nrf2 in myocardial ischemia and   reperfusion injury. Int J Biol Macromol. 2019 Mar 15;125:496-502.

[14] Zhu   M, Liu X*, Wang Y, Chen L, Wang L, Qin X, Xu J, Li L, Tu Y, Zhou T, Sang A, Song   E. YAP via interacting with STAT3 regulates VEGF-induced angiogenesis in   human retinal microvascular endothelial cells. Exp Cell Res. 2018 Dec   15;373(1-2):155-163.

[15] Xue   P, Liu X*, Shen Y, Ju Y, Lu X, Zhang J, Xu G, Sun Y, Chen J, Gu H, Cui Z, Bao G.   E3 Ubiquitin Ligase c-cbl Inhibits Microglia Activation After Chronic Constriction   Injury. Neurochem Res. 2018 Aug;43(8):1631-1640.

[16] Liu X*, Li A, Ju Y, Liu W, Shi H, Hu R, Zhou Z, Sun X. β4GalT1 Mediates PPARγ   N-Glycosylation to Attenuate Microglia Inflammatory Activation. Inflammation.   2018 Aug;41(4):1424-1436.

[17] Guo W, Liu X*, Li J, Shen Y, Zhou Z, Wang M,   Xie Y, Feng X, Wang L, Wu X. Prdx1 alleviates cardiomyocyte apoptosis through   ROS-activated MAPK pathway during myocardial ischemia/reperfusion injury. Int   J Biol Macromol. 2018 Jun;112:608-615.

[18] Wang   B, Liu S, Fan B, Xu X, Chen Y, Lu R, Xu Z, Liu X#. PKM2 is involved in neuropathic pain   by regulating ERK and STAT3 activation in rat spinal cord. J Headache Pain.   2018 Jan 18;19(1):7.

[19] Gu   L, Zhao J, Zhang S, Xu W, Ni R, Liu X#. Runt-related   transcription factor 2 (RUNX2) inhibits apoptosis of intestinal epithelial   cells in Crohn's disease. Pathol Res Pract. 2018 Feb;214(2):245-252.

[20] Wang   B, Fan B, Dai Q, Xu X, Jiang P, Zhu L, Dai H, Yao Z, Xu Z, Liu X#. Fascin-1 Contributes to Neuropathic   Pain by Promoting Inflammation in Rat Spinal Cord. Neurochem Res. 2018   Feb;43(2):287-296.

[21] Liu X*, Huang S, Liu C, Liu X,   Shen Y, Cui Z. PPP1CC is associated with astrocyte and microglia   proliferation after traumatic spinal cord injury in rats. Pathol Res Pract.   2017 Nov;213(11):1355-1364.

[22] Shao   L, Liu X*, Zhu S, Liu C, Gao Y, Xu X. The Role of Smurf1 in Neuronal Necroptosis   after Lipopolysaccharide-Induced Neuroinflammation. Cell Mol Neurobiol. 2018   May;38(4):809-816.

[23] Song   Y, Liu X*, Feng X, Gu Z, Gu Y, Lian M, Xiao J, Cao P, Zheng K, Gu X, Li D, He P,   Wang C.NRP1 Accelerates Odontoblast Differentiation of Dental Pulp Stem Cells   Through Classical Wnt/β-Catenin Signaling. Cell Reprogram. 2017   Oct;19(5):324-330.

[24] Chen   R, Gong P, Tao T, Gao Y, Shen J, Yan Y, Duan C, Wang J, Liu X#. O-GlcNAc Glycosylation of nNOS   Promotes Neuronal Apoptosis Following Glutamate Excitotoxicity. Cell Mol   Neurobiol. 2017 Nov;37(8):1465-1475.

[25] Zhang   C, Liu X*, Miao J, Wang S, Wu L, Yan D, Li J, Guo W, Wu X, Shen A. Heat   shock protein 70 protects cardiomyocytes through suppressing SUMOylation and   nucleus translocation of phosphorylated eukaryotic elongation factor 2 during   myocardial ischemia and reperfusion. Apoptosis. 2017 May;22(5):608-625.

[26] Zhu   M, Liu X*, Wang S, Miao J, Wu L, Yang X, Wang Y, Kang L, Li W, Cui C, Chen H,   Sang A. PKR promotes choroidal neovascularization via upregulating the   PI3K/Akt signaling pathway in VEGF expression. Mol Vis. 2016 Dec   2;22:1361-1374.

[27] Liu X*, Yan D, Li Y, Sha X, Wu K, Zhao J, Yang C, Zhang C, Shi J, Wu X.   Erythroblast transformation-specific 2 correlates with vascular smooth muscle   cell apoptosis in rat heterotopic heart transplantation model. J Thorac Dis.   2016 Aug;8(8):2027-2037.

[28] Liu X*, Zhu M, Yang X, Wang Y, Qin B, Cui C, Chen H, Sang A. Inhibition of   RACK1 ameliorates choroidal neovascularization formation in vitro and in   vivo. Exp Mol Pathol. 2016 Jun;100(3):451-459.

[29] Liu   X, Huang Y, Zhang Y, Li X, Liu C, Huang S, Xu D, Wu Y, Liu X#. T-cell factor (TCF/LEF1) binding elements   (TBEs) of FasL (Fas ligand or CD95 ligand) bind and cluster Fas (CD95) and   form complexes with the TCF-4 and b-catenin transcription factors in vitro   and in vivo which result in triggering cell death and/or cell activation.   Cell Mol Neurobiol. 2016 Aug;36(6):1001-1013.

[30] Zhang   Y, Liu X*, Xue H, Liu X, Dai   A, Song Y, Ke K, Cao M. Upregulation of PRDM5 Is Associated with Astrocyte   Proliferation and Neuronal Apoptosis Caused by Lipopolysaccharide. J Mol   Neurosci. 2016 May;59(1):146-157.

[31] Liu X*, Yang X, Zhu R, Dai M, Zhu M, Shen Y, Fang H, Sang A, Chen   H. Involvement of Fra-1 in Retinal Ganglion Cell Apoptosis in Rat   Light-Induced Retina Damage Model. Cell Mol Neurobiol. 2017 Jan;37(1):83-92.

[32] Liu X*, Zhang C, Qian L, Zhang C, Wu K, Yang C, Yan D, Wu X, Shi J. NF45   inhibits cardiomyocyte apoptosis following myocardial ischemia-reperfusion   injury. Pathol Res Pract. 2015 Dec;211(12):955-962.

[33] Lin   Y, Xu D, Li X, Liu C, Liu X, Huang S, Huang Y, Liu X#. Upregulation of Interferon Regulatory   Factor 6 Promotes Neuronal Apoptosis After Traumatic Brain Injury in Adult   Rats. Cell Mol Neurobiol. 2016 Jan;36(1):27-36.

[34] Shi   J, Wu K, Yang X, Yan D, Qian L, Zhang C, Yang C, Zhang C, Wu X, Liu X#. Nur77 is involved in graft infiltrating T   lymphocyte apoptosis in rat cardiac transplantation model. Pathol Res Pract.   2015 Sep;211(9):633-640.

[35] Huang   S, Liu X*, Zhang J, Bao G, Xu G, Sun Y, Shen Q, Lian M, Huang Y, Cui Z.   Expression of Peroxiredoxin 1 After Traumatic Spinal Cord Injury in Rats.   Cell Mol Neurobiol. 2015 Nov;35(8):1217-1226.

[36] Yang   X, Chen H, Zhu M, Zhu R, Qin B, Fang H, Dai M, Sang A, Liu X#. Up-Regulation of PKM2 Relates to Retinal   Ganglion Cell Apoptosis After Light-Induced Retinal Damage in Adult Rats.   Cell Mol Neurobiol. 2015 Nov;35(8):1175-1186.

[37] Sang   A, Yang X, Chen H, Qin B, Zhu M, Dai M, Zhu R, Liu X#. Upregulation of SYF2 Relates to Retinal   Ganglion Cell Apoptosis and Retinal Glia Cell Proliferation After   Light-Induced Retinal Damage. J Mol Neurosci. 2015 Jun;56(2):480-490.

[38] Liu X*, Yuan D, Nie X, Shen J, Yan Y, Zhang D, Gu J. BTEB2 prevents neuronal   apoptosis via promoting bad phosphorylation in rat intracerebral hemorrhage   model. J Mol Neurosci. 2015 Jan;55(1):206-216.

[39] Liu X*, Cheng C, Shao B, Wu X, Ji Y, Lu X, Shen A. LPS-stimulating   astrocyte-conditioned medium causes neuronal apoptosis via increasing   CDK11(p58) expression in PC12 cells through downregulating AKT pathway. Cell   Mol Neurobiol. 2013 Aug;33(6):779-787.

[40] Liu X*, Cheng C, Shao B, Wu X, Ji Y, Lu X, Shen A. The functional interaction   between CDK11p58 and β-1,4-galactosyltransferase I involved in astrocyte   activation caused by lipopolysaccharide. Inflammation. 2012   Aug;35(4):1365-1377.

[41] Liu X*, Cheng C, Shao B, Wu X, Ji Y, Liu Y, Lu X, Shen A. CDK11(p58) promotes   rat astrocyte inflammatory response via activating p38 and JNK pathways   induced by lipopolysaccharide. Neurochem Res. 2012 Mar;37(3):563-573.

注:*第一作者,#通讯作者。

专利(按时间倒序排序)

[1] 刘晓娟;朱曼辉;孙晓雷;李爱红;郭爱松,MLN4924在制备脉络膜新生血管治疗药物中的应用,20220506日授权,专利号ZL202010468240.X

[2] 刘晓娟;沈爱国;朱曼辉;陈辉,62aa多肽类似物及其载体和应用,20200310日授权,专利号ZL201610351478.8

[3] 刘晓娟;沈爱国;颜大亮;史加海,抗CAV的多肽类似物和对应的cDNA及应用,20181116日授权,专利号ZL201610071300.8