姓名：解刚才
职称：教授
个人简介：教授、博士生导师、高层次引进人才、江苏省特聘教授。中国科学技术大学生物学本科，中国科学院计算生物学博士，美国哥伦比亚大学及费城儿童医院博士后。主要从事基于多组学大数据的计算生物学研究，代表性研究成果发表于《Nature》、《AJHG》、《Cell Discovery》等国际知名期刊杂志上，文章总引用率超过1500次。当前主要从事基于多组学大数据的衰老相关基因调控机理研究及抗衰老药物开发。现任江苏省生物信息学专委会委员，江苏省免疫学会基础免疫专委会委员，南通市医学信息学会常务理事。
专业研究领域：基础医学、生物信息学、基因组学、人工智能、衰老。
专著与论集：
（# 通讯作者，*共同第一作者）
1. Jichang Wang*, Gangcai Xie*, Singh M, Ghanbarian AT, Raskó T, Szvetnik A, Cai H, Besser D,Prigione A, Fuchs NV, Schumann GG, Chen W, Lorincz MC, Ivics Z, Hurst LD#, Izsvák Z#. Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells. Nature. Dec 2014.
2. Shi, J.*, K. L. Fok*, P. Dai*, F. Qiao, M. Zhang, H. Liu, M. Sang, M. Ye, Y. Liu, Y. Zhou, C. Wang, F. Sun#, Gangcai Xie#, and H. Chen#. Spatio-Temporal Landscape of Mouse Epididymal Cells and Specific Mitochondria-Rich Segments Defined by Large-Scale Single-Cell Rna-Seq. Cell Discovery. 2021.
3. Jung Hoon Son*, Gangcai Xie*, Chi Yuan, Lyudmila Ena, Ziran Li, Andrew Goldstein, Lulin Huang, Liwei Wang, Feichen Shen, Hongfang Liu, Karla Mehl, Emily E Groopman, Maddalena Marasa, Krzysztof Kiryluk, Ali G Gharavi, Wendy K Chung, George Hripcsak, Carol Friedman, Chunhua Weng#, Kai Wang#. Deep phenotyping on electronic health records facilitates genetic diagnosis by clinical exomes. The American Journal of Human Genetics. 2018.
4. Yunwei Shi*, Xuchu Duan*, Guangmin Xu*, Xiaoning Wang, Guanyun Wei, Shikui Dong, Gangcai Xie#, Dong Liu#. A ribosomal DNA-hosted microRNA regulates zebrafish embryonic angiogenesis. Angiogenesis. 2019.
5. Qian F*, Wei G*, Gao Y*, Wang X*, Gong J, Guo C, Wang X, Zhang X, Zhao J, Wang C, Xu M, Hu Y, Yin G, Kang J, Chai R#, Gangcai Xie#, Liu D#. Single-cell RNA-sequencing of zebrafish hair cells reveals novel genes potentially involved in hearing loss. Cellular and Molecular Life Sciences. 2022 Jun 26;79(7):385.
6. Peipei Qian*, Jiahui Kang*, Dong Liu#, Gangcai Xie#. Single cell transcriptome sequencing of zebrafish testis revealed novel spermatogenesis marker genes and stronger Leydig-Germ cell paracrine interactions. Frontiers in Genetics. 2022.
7. Gangcai Xie*; Dong, C*.; Kong, Y.; Zhong, J.F.; Li, M.; Wang, K#. Group Lasso Regularized Deep Learning for Cancer Prognosis from Multi-Omics and Clinical Features. Genes. 2019, 10, 240.
8. Liu J, Jin T, Ran L, Zhao Z, Zhu R, Gangcai Xie#, Bi X#. Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation. Hereditas. 2022 Oct 21;159(1):41.
9. Gangcai Xie#; Xu Zhang; Feng Lv; Mengmeng Sang; Hairong Hu; Jinqiu Wang#; Dong Liu# . Nanopore Sequencing and Hi-C Based De Novo Assembly of Trachidermus fasciatus Genome, Genes, 2021, 12(692).
10. Linsheng Shi*, Changsheng Chen*, Zhenhua Yin*, Guanyun Wei, Gangcai Xie#, Dong Liu#. Systematic profiling of early regulators during tissue regeneration using zebrafish model. Wound Repair and Regeneration. August 2020.
主要科研项目
主持多项省部级以上科研项目，其中包括国家自然科学基金项目1项，江苏省特聘教授人才基金项目1项，江苏省自然科学基金1项。
讲授课程
《医学信息学》、《生殖保健与健康》、《生殖生物学及其进展》等课程生物信息学与基因组学相关章节
指导研究生情况
已毕业硕士生1名；在读博士生3名，硕士生4名。
