姓名：秘晓林
职称：教授
个人简介：1990年毕业于兰州大学，获理学学士学位。1996年毕业于卫生部兰州生物制品研究所，获理学硕士学位。1999年毕业于中国预防医学科学院病毒学研究所，获得博士学位。同年赴美国，在国立卫生研究院国家癌症研究所（National Institutes of Health，National Cancer Institute）从事博士后研究，随后任职美国国立卫生研究院研究员（Title 42 VP fellow）。2019年加入南通大学医学院，现为南通大学二级教授，博士生生导师，校学术委员会委员。入选中国科学院“引进国外杰出人才--百人计划”，辽宁省“攀登学者”。国家重大科学研究计划、国家自然科学基金、博士后科学基金、美国国家科学基金研究生等项目评议人，SCI杂志International Journal of Nanomedicine顾问编委，PLoS ONE、Current Proteomics、中国生化药物杂志编委，中国环境诱变剂学会理事，辽宁省医学会医学遗传学分会副主任委员，Biomaterials、Genetics、Cell Cycle、International Journal of Nanomedicine等期刊审稿人。主持国家重点基础研究计划“973”课题、国家自然科学基金项目等。作为通讯作者，研究成果发表在Proceedings of National Academy of Sciences USA, Oncogene, Human Molecular Genetics, Biomaterials, Journal of Cell Science, Nanotoxicology, Cell Cycle等国际知名学术期刊。
专业研究领域：1. 非编码RNA（miRNA和lncRNA）应答DNA损伤，调节染色质重构、细胞周期、凋亡的功能和机制；2.干细胞再生与分化的表观遗传调控。
专著与论集（代表性论文）：
1. Xu, Qi, Liu, Jun, Du, Xiao, Xue, Di, Li, Dong, and Bi, Xiaolin*. Long noncoding RNA CR46040 is essential for injury-stimulated regeneration of intestinal stem cells in Drosophila. Genetics, (2023). IF: 4.4
2. Dong, Li, Ying, Ge, Ze, Zhao, Rui, Zhu, Xiang, Wang, and Xiaolin, Bi*. Distinct and Coordinated Regulation of Small Non-coding RNAs by E2f1 and p53 During Drosophila Development and in Response to DNA Damage. Frontiers in Cell and Developmental Biology 9, (2021): 695311.IF: 6.1
3. Zhaoxia Dai; Dong Li; Xiao Du; Ying Ge; Deborah A. Hursh; Xiaolin Bi*, Drosophila Caliban preserves intestinal homeostasis and lifespan through regulating mitochondrial dynamics and redox state in enterocytes, PLoS Genetics, 2020, 16(10): e1009140. IF: 5.9
4. Li D., Liu Y., Pei C., Zhang P., Pan L., Xiao J., Meng S., Yuan Z., Bi X. * miR-285-Yki/Mask double-negative feedback loop mediates blood-brain barrier integrity in Drosophila. Proceedings of National Academy of Sciences USA. 2017. 114(12):E2365-E2374. IF 9.5
5. Song F., Li D., Wang Y., Bi X.* Drosophila Caliban mediates G1-S transition and ionizing radiation induced S phase checkpoint. Cell Cycle. 2018. 17(18): 2256-2267. IF 3.3
6. Cong W., Wang P., Qu Y., Tang J., Bai R., Zhao Y., Chen C. , Bi X. * Evalutation of the influence of Fullerenol on aging and stress resistance using Caenorhabditis elegans. Biomaterials. 2015. 42:78-86. IF 8.6
7. Chen H., Wang B., Feng W., Du W., Ouyang H., Chai Z., Bi X.* Oral Magnetite Nanoparticles Disturb the Development of Drosophila Melanogaster from Oogenesis to Adult Emergence. Nanotoxicology. 2015. 9(3):302-312. IF 7.9
8. Fang G., Zhang D., Yin H., Zheng L., Bi X.*, Yuan L.* Centlein maintains centrosome cohesion by bridging an interaction between C-Nap1 and Cep68. Journal of Cell Science. 2014. 127:1631-1639. IF 5.4
9. Wang Y., Wang Z., Joshi BH., Puri R., Stultz B., Yuan Q., Bai Y., Zhou P., Yuan Z., Hursh DA., Bi X.* The tumor suppressor Caliban regulates DNA damage induced apoptosis through p53-dependent and –independent activity. Oncogene. 2013. 32(33):3857-3866. IF 8.6
10. Liu W., Jiang F., Bi X.*, Zhang Q*. Drosophila FMRP participates in DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis. Human Molecular Genetics. 2012, 21(21):4655-4668. IF 7.7
11. Kong L., Yuan Y., Zhu H., Li Y., Guo Q., Zhao Y., Wang Q., Bi X.*, Gao X*. The suppression of prostate LNCaP cancer cells growth by Selenium nanoparticles through Akt/Mdm2/AR controlled apoptosis. Biomaterials. 2011.32(27)：6515-6522. IF 7.6
12. Gao G., Bi X., Chen J., Srikanta D., Rong YS. Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis. Proceedings of National Academy of Sciences USA. 2009. 106(26): 10728–10733. (Equal contribution). IF 9.4
13. Bi X., Jones T., Abbasi F., Lee H., Stultz B., Hursh D., Mortin M. Drosophila Caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. Oncogene. 2005. 24:8229-8239. IF 6.8
14. Bi X., Srikanta D., Fanti L., Pimpinelli S., Badugu R., Kellum R., Rong Y.S. Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance. Proceedings of National Academy of Sciences USA. 2005. 102(42):15167-15172. IF 10.2
15. Bi X., Wei S.D., Rong Y.S. Telomere protection without a telomerase: the role of ATM and Mre11 in Drosophila telomere maintenance. Current Biology. 2004. 14:1348-1353. IF 11.9
16. Bi X., Kajava A., Demidenko Z., Jones T., Mortin M. The carboxyl terminus of Prospero regulates its subcellular localization. Molecular and Cellular Biology. 2003. 23 (3): 1014-1024. IF 8.9
主要科研项目
主持多项省部级以上科研项目，其中包括国家重点基础研究计划“973”课题1项、国家自然科学基金面上项目5项。
