姓名：顾云娟

职称：教授，主任医师

个人简介：江苏南通人，医学博士。

专业研究领域：糖尿病与肥胖症的临床与基础研究。

专著与论集（近5年）：

1.        Yan Jin,Runze Wu,Li Li,Lihua Shen,Yunjuan Gu,Cheng Sun.Exosomes from Inflamed Macrophages Promote the Progression of Parkinson’s Disease by Inducing Neuroinflammation. Mol Neurobiol (2023). https://doi.org/10.1007/s12035-022-03179-6

2.        Shenghan Ji, Chen Dong, Rou Chen, Chenchen Shen, Jing Xiao, Yunjuan Gu and Jianlin Gao. Effects of Variability in Glycemic Indices on Longevity in Chinese Centenarians. Frontiers in Nutrition, 08 July 2022, 2022: 955101.

3.         Jie Xu , Li Jin, Yi Sun, Rong Zhang, Xianghui Chen , Ranran Zhou, YunJuan Gu, Cheng Hu. 12(S)-Hydroxyeicosatetraenoic Acid Is Significantly Increased in Diabetic Kidney Disease and Associated with Renal Function Decline. Diabetes Metab Res Rev. 2022 Jun 6;e3554.

4.        Jie Xu, Li Jin, Jie Chen, Rong Zhang, Hong Zhang, Yangyang Li, Danfeng Peng, Yunjuan Gu, Michael B. Wheeler, Cheng Hu. Common variants in genes involved in islet amyloid polypeptide (IAPP) processing and the degradation pathway are associated with T2DM risk: A Chinese population study. Diabetes Research and Clinical Practice, 2022.Feb,4: 185 (2022) 109235.

5.        Ping Huang, Xiaoqin Zhao, Yi Sun, Xinlei Wang, Rong Ouyang, Yanqiu Jiang, Xiaoquan Zhang, Renyue Hu, Zhuqi Tang, Yunjuan Gu. Fatty Acid-Binding Protein 4 in Patients with and without Diabetic Retinopathy. Diabetes Metab J, 2022 Jul;46(4):640-649.

6.        Feng Jiang, Jing Yan, Rong Zhang, Xiaojing Ma, Yuqian Bao, Yujuan Gu and Cheng Hu. Functional Characterization of a Novel Heterozygous Mutation in the Glucokinase Gene That Causes MODY2 in Chinese Pedigrees. Front in Endocrinol. 2021,12:803992.

7.        Yimei Shen, Xiaohua Yang, Xiaojun Han, Wei Xi, Lihua Jiang, Shuqin Wang, Haifeng Zhong, Yunjuan Gu. Influence of GLP-1 receptor agonist on insulin dosage and blood glucose control of patients with type 2 diabetes mellitus. Am J Transl Res 2021;13(10):11814-11823.

8.        Jiang Y, Cui S, Zhang R, Zhao X, Yao L, OuYang R, Chen W, Zhou R, Zhao X, Tang Z, Yuan J, Yuan J, Qian C, Huang P, Gu Y, Wang X. Shift of Glucose PeakTime During Oral Glucose Tolerance Test is Associated with Changes in Insulin Secretion and Insulin Sensitivity After Therapy with Antidiabetic Drugs in Patients with Type 2 Diabetes. Diabetes Ther. 2021 Sep;12(9):2437-2450.

9.        Jing Xiao, Jingyi Lv, Shiyu Wang, Yang Zhou1, Lunwen Chen, Juying Lu, Xiaoyi Zhang, Xiaojian Wang, Yunjuan Gu and Qingyun Lu. Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study. BMC Geriatrics (2021) 21:391.

10.     Yiqian Zhang, Tong Yin, Xinlei Wang, Rongping Zhang, Jie Yuan, Yi Sun, Jing Zong, Shiwei Cui, Yunjuan Gu. Relationships between Islet-Specific Autoantibody Titers and the Clinical Characteristics of Patients with Diabetes Mellitus. Diabetes Metab J. 2021 May; 45(3): 404-416.

11.     Jing Zong, Yi Sun , Yiqian Zhang, Jin Yuan, Xinlei Wang, Rongping Zhang , Xiaoqin Zhao, Xuying Zhao, Yunjuan Gu. Correlation Between Serum Uric Acid Level and Central Body Fat Distribution in Patients with Type 2 Diabetes. Diabetes Metab Syndr Obes. 2020 Jul 16;13:2521-2531.

12.     Yuan, J; Zhang, R; Wu, R; Gu Y; Lu, Y. The effects of oxytocin to rectify metabolic dysfunction in obese mice are associated with increased thermogenesis. Mol Cell Endocrinol. 2020 Jun 09, 514:110903.

13.     Sun Y, Zhu M, Zhao H, Ni X, Chang R, Su J, Huang H, Cui S, Wang X, Yuan J, Yuan J, OuYang R, Zhang R, Chen W, Gu Y, Sun Y. Serum Fibroblast Growth Factor 19 and Total Bile Acid Concentrations Are Potential Biomarkers of Hepatocellular Carcinoma in Patients with Type 2 Diabetes Mellitus. Biomed Res Int. 2020 Feb 11;2020:1751989. doi: 10.1155/2020/1751989. eCollection

14.     Ma H, Yuan J, Jinyu M, Ding J, Lin W, Wang X, Zhang M, Sun Y, Wu R, Liu C, Sun C, Gu Y. BMP7 improves insulin signal transduction in the liver. J Endocrinol. 2019 Nov;243(2):97-110.

15.     Ni X, Gu Y, Yu H, Wang S, Chen Y, Wang X, Yuan X, Jia W. Serum Adipocyte Fatty Acid-Binding Protein 4 Levels Are Independently Associated with Radioisotope Glomerular Filtration Rate in Type 2 Diabetic Patients with Early Diabetic Nephropathy. Biomed Res Int. 2018 May 27;2018:4578140.

16.     Lee PCH, Gu Y, Yeung MY, Fong CHY, Woo YC, Chow WS, Tan K, Lam KSL. Dapagliflozin and Empagliflozin Ameliorate Hepatic Dysfunction Among Chinese Subjects with Diabetes in Part Through Glycemic Improvement: A Single-Center, Retrospective, Observational Study. Diabetes Ther. 2018 Feb;9(1):285-295.

17.     Yi Sun1 Wenhui Qiang, Runze Wu, Tong Yin, Jie Yuan, Jin Yuan and Yunjuan Gu. A glycogen storage disease type 1a patient with type 2 diabetes. BMC Medical Genomics. 2022 Sep 27;15(1):205.

18.     冯媛媛,羌雯慧,肖静,印彤,王鑫蕾,赵絮影,袁洁,顾云娟.GLP-1RAl联合SGLT2i治疗超重/肥胖T2DM患者效果及安全性的临床观察性研究.南通大学学报(医学版),2022,42(2):115-120.

19.     羌雯慧,冯媛媛,印彤,王鑫蕾,袁洁,张荣萍,赵小芹,周冉冉,赵絮影,肖静,顾云娟.甘精胰岛素联合GLP-1受体激动剂治疗超重/肥胖2型糖尿病效果观察.交通医学, 2021,35(5):463-467.

20.     顾云娟,吴尚熹,吕婧怡,周阳,陈伦文,陆青云,鲁菊英,张晓义,梁源源,肖静. 老年糖尿病患病风险与体力活动的关联研究.中国全科医学, 2022, 25(6):750-755.

21.     王鑫蕾,倪晓晴,苏建友,袁瑾,赵小芹,周冉冉,崔世维,蒋燕秋,顾云娟.

AKT/FOXO1信号通路在限热卡高脂饮食改善肥胖小鼠肝脏胰岛素抵抗中的作用. 实用医学杂志. 2020,16 (36):2199-2204.

22.     王鑫蕾.张荣萍.赵小芹.顾云娟.车前草提取物对糖尿病肾病大鼠肾功能、糖脂代谢、炎症及脂肪细胞因子的影响.广西医药, 2020, 42 (12): 1545-1549. (2020-8-25).

23.     张小铨,王鑫蕾,袁瑾,张荣萍,陈炜,袁洁,崔世维,陈丽平,顾云娟. 2型糖尿病患者一相胰岛素分泌功能特点与糖尿病微血管病变的相关性. 第二军医大学学报, 2018, 39 (12):1348-1353.

24.     蒋燕秋,王鑫蕾,顾云娟.口服葡萄糖耐量试验中血糖曲线形态与胰岛功能关系的研究进展.中华糖尿病杂志,2022,14(5):517-520.

25.     沈璇,顾云娟.持续皮下胰岛素注射对糖尿病视网膜病变影响的研究进展.天津医药,2019,47(11):1189-1196.

主要科研项目

主持南通市科研项目2项。

讲授课程

内科学

指导研究生情况

已硕士生20名；在读硕士生11名。