姓名：范义辉
职称：教授
个人简介：江苏海门人，医学博士
专业研究领域：空间基因组学，医学基因组学，表观遗传学，肿瘤学，免疫治疗，自身免疫性疾病，基因功能，蛋白液-液相分离
专著与论集：
1. Xu YP, Wu YC, Zhang SL, et al. A tumor specific super-enhancer drives immune evasion by guiding synchronous expression of PD-L1 and PD-L2. Cell Reports, 29 (11): 3435-3447 (2019).
2. Wu YC, Zhao JW, Zhu HL, et al. SPACE: a web server for linking chromatin accessibility with clinical phenotypes and the immune microenvironment in pan-cancer analysis. Cellular & Molecular Immunology, 17（12）：1294 – 1296. （2020）
3. Wu YC, Yang Y, Gu HY, et al. Multi-omics analysis reveals the functional transcription and potential translation of enhancers. International Journal of Cancer, 147(8):2210-2224. (2020)
4. Guo CL, Ni WK, Ma PP, et al. The endoribonuclease N4BP1 prevents psoriasis by controlling both keratinocytes proliferation and neutrophil infiltration.Cell Death and Disease, 12(5):488. (2021).
5. Fan ZW, Wu CY, Chen MM, et al. The generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation.Acta Pharmaceutica Sinica B, 12(3):1041-1053.(2022)
6. Xiao X #, Fan Yihui #, Li J, et al. Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation. Journal of Experimental Medicine 215(2): 559 – 574 (2018).
7. Xiao X#, Shi XM #, Fan YH#, et. OX40 inhibits Th17 cells through activation of repressive chromatin remodeling pathways. Immunity 44: 1271-1283 (2016).
8. Fan YH, Mao RF, Yu Y, et al.USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. Journal of Experimental Medicine211(2):313-328 (2014).
9. Fan YH #, Ge NL #, Wang XS #, et al. Amplification and over-expression of MAP3K3 gene in human breast cancer promotes formation and survival of breast cancer cells. Journal of Pathology 232(1):75-86 (2014).
10. Fan YH, Yu Y, Mao RF. USP4 targets TAK1 to downregulate TNFa-induced NF-kB activation. Cell Death and Differentiation, 18:1547-1560 (2011).
主要科研项目
主持多项省部级以上科研项目，其中包括国家自然科学基金项目4项，江苏省自然科学基金1项，江苏省特聘教授基金。
讲授课程
病原生物学，科研思维案例教学，病原生物学研究进展
指导研究生情况
已毕业博士研究生1名，硕士生7名；在读博士生2名，硕士生5名。
